,
Nikhil Chandra Roy,
Ansari Muhammad Abdul Jalil,
Rita Rani Barua,
Sushanta Barua*
Background: Gastrointestinal (GI) symptoms have become increasingly recognized as a significant aspect of COVID-19. However, the long-term impact of GI symptoms on disease course, outcomes, and post-discharge sequelae remains poorly understood. This study aimed to investigate the disease course, outcomes, and long-term sequelae of hospitalized COVID-19 patients with and without GI symptoms. Methods: A prospective cohort study was conducted on 246 hospitalized COVID-19 patients at Dhaka Medical College Hospital. Participants were divided into two groups: 123 with GI symptoms and 123 without. Clinical outcomes during hospitalization and post-discharge follow-up were compared between the two groups. Results: Patients with GI symptoms demonstrated better in-hospital outcomes, including lower oxygen requirements and a higher frequency of complete recovery. However, rates of ICU admission, mechanical ventilation, and mortality were similar between both groups. Long-term follow-up revealed comparable rates of post-COVID-19 symptoms in both groups, with persistent symptoms being more common than new symptoms. Conclusion: Our study found that patients with GI symptoms had better in-hospital outcomes regarding oxygen requirements and complete recovery. However, long-term post-discharge sequelae were similar in both groups. These findings highlight the importance of ongoing research to better understand the long-term impact of COVID-19, including the potential role of GI symptoms in disease course and outcomes.
| Published in | International Journal of Gastroenterology (Volume 8, Issue 2) |
| DOI | 10.11648/j.ijg.20240802.13 |
| Page(s) | 67-75 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
COVID-19, SARS-CoV-2, Gastrointestinal Symptoms, Outcomes, Post-COVID-19 Syndrome
| [1] | C. H., Y., W., & X., L. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395, 497-506. |
| [2] | Phelan, A. L., & K., R. (2020). The novel coronavirus originating in Wuhan, China: Challenges for global health governance. JAMA, 323, 709-10. |
| [3] | H, L.-Q., N, A., & YY, T. (2020). Are high-performing health systems resilient against the COVID-19 epidemic? Lancet, 395, 848-50. |
| [4] | P, W., N, A., & Y, P. (2020). The SARS-CoV-2 outbreak: Diagnosis, infection prevention, and public perception. Clinical Chemistry. |
| [5] | BE, Y., SWX, O., & S, K. (2020). Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore. JAMA. |
| [6] | C., M, Z., & X, D. (2020). Epidemiologic and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study. Lancet, 395, 507-13. |
| [7] | Gao, Q. Y., & C., Y. (2020). 2019 novel coronavirus infection and gastrointestinal tract. Journal of Digestive Diseases. |
| [8] | Huang, C., Huang, L., Wang, Y., & Li, X. (2021). 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet, 397, 220-32. |
| [9] | S, R., JS, H., & M, N. (2020). Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA, 323(20), 2052. |
| [10] | Pan, L., Mu, M., & Yang, P. (2020). Clinical Characteristics of COVID-19 Patients With Digestive Symptoms in Hubei, China: A Descriptive, Cross-Sectional, Multicenter Study. American Journal of Gastroenterology, 115(5), 766-773. |
| [11] | Luo, S., Jiang, X., & Zhang, Z. (2020). Don't Overlook Digestive Symptoms in Patients With 2019 Novel Coronavirus Disease (COVID-19). Clinical Gastroenterology and Hepatology, 18(7), 1636-1637. |
| [12] | Reed, W., Zhou, J., Onukogu, I., & Ghanta, S. (2020). Prevalence and Characteristics of Gastrointestinal Symptoms in Patients with Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the United States: A Multicenter Cohort Study. Gastroenterology, 159(2), 765-767. |
| [13] | Laszkowka, M., Faye, A., & Kim, J. (2021). Disease Course and Outcomes of COVID-19 among Hospitalized Patients with Gastrointestinal Manifestations. Clinical Gastroenterology and Hepatology, 19(7), 1402-1409. |
| [14] | Siddiqui, A. A., Abro, B., & Bhatti, J. M. (2021). Clinical Outcome of COVID-19 Patients Presenting With Gastrointestinal Symptoms. Cureus, 13(6), e15710. |
| [15] | Nabil, A., Fallouh, K., H., & Chichi, O. (2021). Better clinical outcomes in hospitalized COVID-19. Journal of the National Medical Association, 17(2). |
| [16] | Fahad, G., Kevin, B., & Julie, P. (2020). Meta-analysis of outcomes of patients with COVID-19 infection with versus without gastrointestinal symptoms. Baylor University Medical Center Proceedings, 33(3), 366-369. |
| [17] | Hajifathalian, K., Krisko, T., & Mehta, A. (2020). Gastrointestinal and Hepatic Manifestations of 2019 Novel Coronavirus Disease in a Large Cohort of Infected Patients from New York: Clinical Implications. Journal of Gastroenterology, 159(3), 1137-1140. |
| [18] | Cao, C., He, L., Ma, J., Chen, M., Li, Y., Jiang, Q., Wu, S., Yu, L., Huang, W., Qian, G., Zhu, C., Chu, J., Chen, X. (2020). Clinical features and predictors for patients with severe SARS-CoV-2 pneumonia at the start of the pandemic: a retrospective multicenter cohort study. BMC Infectious Diseases, 21(1), 666. doi: 10.1186/s12879-021-06335-w |
| [19] | Kayasslan, B., Eser, F., & Kalem, K. A. (2021). Post-COVID syndrome: A single-center questionnaire study on 1007 participants recovered from COVID-19. Journal of Medical Virology. 20. Crook, H., Raza, S., & Edison, P. (2021). Long COVID—mechanisms, risk factors, and management. British Medical Journal, 374, 1648. |
| [20] | Crook, H., Raza, S., & Edison, P. (2021). Long covid—mechanisms, risk factors, and management. BMJ, 374, 1648. |
| [21] | Carod-Artal, F. (2021). Post-COVID-19 syndrome: epidemiology, diagnostic criteria and implicated pathogenic mechanisms. Revista de Neurología, 72, 384-396. |
APA Style
Sikder, U. K., Aftab, H., Roy, N. C., Jalil, A. M. A., Barua, R. R., et al. (2024). Impact of Gastrointestinal Symptoms on in-Hospital Outcomes and Long-Term Sequelae in Hospitalized COVID-19 Patients: A Prospective Cohort Study. International Journal of Gastroenterology, 8(2), 67-75. https://doi.org/10.11648/j.ijg.20240802.13
ACS Style
Sikder, U. K.; Aftab, H.; Roy, N. C.; Jalil, A. M. A.; Barua, R. R., et al. Impact of Gastrointestinal Symptoms on in-Hospital Outcomes and Long-Term Sequelae in Hospitalized COVID-19 Patients: A Prospective Cohort Study. Int. J. Gastroenterol. 2024, 8(2), 67-75. doi: 10.11648/j.ijg.20240802.13
AMA Style
Sikder UK, Aftab H, Roy NC, Jalil AMA, Barua RR, et al. Impact of Gastrointestinal Symptoms on in-Hospital Outcomes and Long-Term Sequelae in Hospitalized COVID-19 Patients: A Prospective Cohort Study. Int J Gastroenterol. 2024;8(2):67-75. doi: 10.11648/j.ijg.20240802.13
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Download@article{10.11648/j.ijg.20240802.13,
author = {Uzzal Kumar Sikder and Hafeza Aftab and Nikhil Chandra Roy and Ansari Muhammad Abdul Jalil and Rita Rani Barua and Sushanta Barua},
title = {Impact of Gastrointestinal Symptoms on in-Hospital Outcomes and Long-Term Sequelae in Hospitalized COVID-19 Patients: A Prospective Cohort Study
},
journal = {International Journal of Gastroenterology},
volume = {8},
number = {2},
pages = {67-75},
doi = {10.11648/j.ijg.20240802.13},
url = {https://doi.org/10.11648/j.ijg.20240802.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20240802.13},
abstract = {Background: Gastrointestinal (GI) symptoms have become increasingly recognized as a significant aspect of COVID-19. However, the long-term impact of GI symptoms on disease course, outcomes, and post-discharge sequelae remains poorly understood. This study aimed to investigate the disease course, outcomes, and long-term sequelae of hospitalized COVID-19 patients with and without GI symptoms. Methods: A prospective cohort study was conducted on 246 hospitalized COVID-19 patients at Dhaka Medical College Hospital. Participants were divided into two groups: 123 with GI symptoms and 123 without. Clinical outcomes during hospitalization and post-discharge follow-up were compared between the two groups. Results: Patients with GI symptoms demonstrated better in-hospital outcomes, including lower oxygen requirements and a higher frequency of complete recovery. However, rates of ICU admission, mechanical ventilation, and mortality were similar between both groups. Long-term follow-up revealed comparable rates of post-COVID-19 symptoms in both groups, with persistent symptoms being more common than new symptoms. Conclusion: Our study found that patients with GI symptoms had better in-hospital outcomes regarding oxygen requirements and complete recovery. However, long-term post-discharge sequelae were similar in both groups. These findings highlight the importance of ongoing research to better understand the long-term impact of COVID-19, including the potential role of GI symptoms in disease course and outcomes.
},
year = {2024}
}
TY - JOUR T1 - Impact of Gastrointestinal Symptoms on in-Hospital Outcomes and Long-Term Sequelae in Hospitalized COVID-19 Patients: A Prospective Cohort Study AU - Uzzal Kumar Sikder AU - Hafeza Aftab AU - Nikhil Chandra Roy AU - Ansari Muhammad Abdul Jalil AU - Rita Rani Barua AU - Sushanta Barua Y1 - 2024/11/26 PY - 2024 N1 - https://doi.org/10.11648/j.ijg.20240802.13 DO - 10.11648/j.ijg.20240802.13 T2 - International Journal of Gastroenterology JF - International Journal of Gastroenterology JO - International Journal of Gastroenterology SP - 67 EP - 75 PB - Science Publishing Group SN - 2640-169X UR - https://doi.org/10.11648/j.ijg.20240802.13 AB - Background: Gastrointestinal (GI) symptoms have become increasingly recognized as a significant aspect of COVID-19. However, the long-term impact of GI symptoms on disease course, outcomes, and post-discharge sequelae remains poorly understood. This study aimed to investigate the disease course, outcomes, and long-term sequelae of hospitalized COVID-19 patients with and without GI symptoms. Methods: A prospective cohort study was conducted on 246 hospitalized COVID-19 patients at Dhaka Medical College Hospital. Participants were divided into two groups: 123 with GI symptoms and 123 without. Clinical outcomes during hospitalization and post-discharge follow-up were compared between the two groups. Results: Patients with GI symptoms demonstrated better in-hospital outcomes, including lower oxygen requirements and a higher frequency of complete recovery. However, rates of ICU admission, mechanical ventilation, and mortality were similar between both groups. Long-term follow-up revealed comparable rates of post-COVID-19 symptoms in both groups, with persistent symptoms being more common than new symptoms. Conclusion: Our study found that patients with GI symptoms had better in-hospital outcomes regarding oxygen requirements and complete recovery. However, long-term post-discharge sequelae were similar in both groups. These findings highlight the importance of ongoing research to better understand the long-term impact of COVID-19, including the potential role of GI symptoms in disease course and outcomes. VL - 8 IS - 2 ER -
Sheikh Russel National Gastroliver Institute and Hospital, Dhaka, Bangladesh
Bangladesh Institute of Science, General Hospital, Dhaka, Bangladesh
Department of Endocrinology Principal, Mokbul Hossain Samorita Medical College, Tejgoan, Dhaka, Bangladesh
Department of Pathology, Dr. Sirajul Islam Medical College, Dhaka, Bangladesh
Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
