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Comparison Between Seromarkers and Transient Elastography for Assessment of Significant Liver Fibrosis in NAFLD Patients

Received: 20 December 2021     Accepted: 19 January 2022     Published: 9 February 2022
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Abstract

Background: Transient elastography is very sensitive noninvasive tool to assess liver fibrosis in NAFLD patients. But it is costly and not widely available There are also seromarkers (APRI & FBI4) for ruling out significant liver fibrosis. This study intends to compare between seromakers & transient elastography result for assessment of significant liver fibrosis (SF) in NAFDL patients. Methods: This was an observational cross sectional study done in Sheikh Russel National Gastroliver Institute & Hospital from April 2019 to December 2019. A total 111 patients were selected by purposive sampling method. Demographic, clinical and biochemical data were collected. Liver fibrosis was assessed by transient elastography. Aspertate transaminase (ASI) to platelet ratio index (APRI) & FIB-4 score were compared among the non-significant fibrosis (F2-F4) patients. Result: The total number of study population was 111, among them 39 (35.3%) had significant liver fibrosis (Kpa>7.2; F0 to F1). There was significant difference in between SF & non SF groups in terms of mean serum ALT, AST, albumin and platelet count. APRT and FIB-4 were significantly higher in SF group. APRI had better accuracy (area under the receiver operating characteristics curve=0.925) than FIB-4) 0.885) in ruling out SF. Conclusion: Seromarkers are comparable to transient elastography in assessment of significant liver fibrosis in NAFLD patients. Among them APRI is more accurate in determining significant fibrosis.

Published in International Journal of Gastroenterology (Volume 6, Issue 1)
DOI 10.11648/j.ijg.20220601.11
Page(s) 1-4
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Transient Elastography, NAFLD, Significant Fibrosis, Non-significant Fibrosis, Seromakers

References
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Cite This Article
  • APA Style

    Md. Nuruzzaman, Sanjoy Kumar Saha, Mohammad Ashaduzzaman, Mohammed Obayedur Rahman, Amitav Saha, et al. (2022). Comparison Between Seromarkers and Transient Elastography for Assessment of Significant Liver Fibrosis in NAFLD Patients. International Journal of Gastroenterology, 6(1), 1-4. https://doi.org/10.11648/j.ijg.20220601.11

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    ACS Style

    Md. Nuruzzaman; Sanjoy Kumar Saha; Mohammad Ashaduzzaman; Mohammed Obayedur Rahman; Amitav Saha, et al. Comparison Between Seromarkers and Transient Elastography for Assessment of Significant Liver Fibrosis in NAFLD Patients. Int. J. Gastroenterol. 2022, 6(1), 1-4. doi: 10.11648/j.ijg.20220601.11

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    AMA Style

    Md. Nuruzzaman, Sanjoy Kumar Saha, Mohammad Ashaduzzaman, Mohammed Obayedur Rahman, Amitav Saha, et al. Comparison Between Seromarkers and Transient Elastography for Assessment of Significant Liver Fibrosis in NAFLD Patients. Int J Gastroenterol. 2022;6(1):1-4. doi: 10.11648/j.ijg.20220601.11

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  • @article{10.11648/j.ijg.20220601.11,
      author = {Md. Nuruzzaman and Sanjoy Kumar Saha and Mohammad Ashaduzzaman and Mohammed Obayedur Rahman and Amitav Saha and Sajalendu Biswas and Touhidul Karim Majumder and Faruque Ahmed and Nadia Farha and Dr. Suparna Pramanik},
      title = {Comparison Between Seromarkers and Transient Elastography for Assessment of Significant Liver Fibrosis in NAFLD Patients},
      journal = {International Journal of Gastroenterology},
      volume = {6},
      number = {1},
      pages = {1-4},
      doi = {10.11648/j.ijg.20220601.11},
      url = {https://doi.org/10.11648/j.ijg.20220601.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20220601.11},
      abstract = {Background: Transient elastography is very sensitive noninvasive tool to assess liver fibrosis in NAFLD patients. But it is costly and not widely available There are also seromarkers (APRI & FBI4) for ruling out significant liver fibrosis. This study intends to compare between seromakers & transient elastography result for assessment of significant liver fibrosis (SF) in NAFDL patients. Methods: This was an observational cross sectional study done in Sheikh Russel National Gastroliver Institute & Hospital from April 2019 to December 2019. A total 111 patients were selected by purposive sampling method. Demographic, clinical and biochemical data were collected. Liver fibrosis was assessed by transient elastography. Aspertate transaminase (ASI) to platelet ratio index (APRI) & FIB-4 score were compared among the non-significant fibrosis (F2-F4) patients. Result: The total number of study population was 111, among them 39 (35.3%) had significant liver fibrosis (Kpa>7.2; F0 to F1). There was significant difference in between SF & non SF groups in terms of mean serum ALT, AST, albumin and platelet count. APRT and FIB-4 were significantly higher in SF group. APRI had better accuracy (area under the receiver operating characteristics curve=0.925) than FIB-4) 0.885) in ruling out SF. Conclusion: Seromarkers are comparable to transient elastography in assessment of significant liver fibrosis in NAFLD patients. Among them APRI is more accurate in determining significant fibrosis.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Comparison Between Seromarkers and Transient Elastography for Assessment of Significant Liver Fibrosis in NAFLD Patients
    AU  - Md. Nuruzzaman
    AU  - Sanjoy Kumar Saha
    AU  - Mohammad Ashaduzzaman
    AU  - Mohammed Obayedur Rahman
    AU  - Amitav Saha
    AU  - Sajalendu Biswas
    AU  - Touhidul Karim Majumder
    AU  - Faruque Ahmed
    AU  - Nadia Farha
    AU  - Dr. Suparna Pramanik
    Y1  - 2022/02/09
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijg.20220601.11
    DO  - 10.11648/j.ijg.20220601.11
    T2  - International Journal of Gastroenterology
    JF  - International Journal of Gastroenterology
    JO  - International Journal of Gastroenterology
    SP  - 1
    EP  - 4
    PB  - Science Publishing Group
    SN  - 2640-169X
    UR  - https://doi.org/10.11648/j.ijg.20220601.11
    AB  - Background: Transient elastography is very sensitive noninvasive tool to assess liver fibrosis in NAFLD patients. But it is costly and not widely available There are also seromarkers (APRI & FBI4) for ruling out significant liver fibrosis. This study intends to compare between seromakers & transient elastography result for assessment of significant liver fibrosis (SF) in NAFDL patients. Methods: This was an observational cross sectional study done in Sheikh Russel National Gastroliver Institute & Hospital from April 2019 to December 2019. A total 111 patients were selected by purposive sampling method. Demographic, clinical and biochemical data were collected. Liver fibrosis was assessed by transient elastography. Aspertate transaminase (ASI) to platelet ratio index (APRI) & FIB-4 score were compared among the non-significant fibrosis (F2-F4) patients. Result: The total number of study population was 111, among them 39 (35.3%) had significant liver fibrosis (Kpa>7.2; F0 to F1). There was significant difference in between SF & non SF groups in terms of mean serum ALT, AST, albumin and platelet count. APRT and FIB-4 were significantly higher in SF group. APRI had better accuracy (area under the receiver operating characteristics curve=0.925) than FIB-4) 0.885) in ruling out SF. Conclusion: Seromarkers are comparable to transient elastography in assessment of significant liver fibrosis in NAFLD patients. Among them APRI is more accurate in determining significant fibrosis.
    VL  - 6
    IS  - 1
    ER  - 

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Author Information
  • Department of Gastroenterology, Sheik Russel National Gastro Liver Institute and Hospital, Dhaka, Bangladesh

  • Department of Medicine, Bashundhara Ad-din Medical College, Dhaka, Bangladesh

  • Department of Medicine, Bashundhara Ad-din Medical College, Dhaka, Bangladesh

  • Department of Gastroenterology, Sheik Russel National Gastro Liver Institute and Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Dhaka Medical College and Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Shaheed Suharawardy Medical College Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Sheik Russel National Gastro Liver Institute and Hospital, Dhaka, Bangladesh

  • Department of Gastroenterology, Sheik Russel National Gastro Liver Institute and Hospital, Dhaka, Bangladesh

  • Department of Pharmacology, Holy Family Red Crescent Medical College, Dhaka, Bangladesh

  • Directorate General of Health Services, Dhaka, Bangladesh

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