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Incidence of Gastric Cancer in the Patients with Schizophrenia: A Meta-analysis

Received: 9 July 2021     Accepted: 26 July 2021     Published: 2 August 2021
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Abstract

Background: Several studies have reported the incidence of gastric cancer (GC) in the patients with schizophrenia, but the incidence of GC in schizophrenia patients remains controversy. It is necessary to perform a meta-analysis to detect the incidence of GC in schizophrenia patients. Methods: We search the relevant articles from PubMed, EMBASE, Web of Science, the Cochrane Library and Chinese electronic databases. The incidence of GC in schizophrenia patients and heterogeneity were analyzed with STATA10.0 software. Results: Our meta-analysis included total 283,422 patients with schizophrenia and 1,024 patients with GC in nine articles. The incidence of GC in schizophrenia patients was 0.62% (95%CI: 0.005-0.008; P<0.001), but there is obvious heterogeneity (I2=98.7%). We next performed subgroup analysis to explore the incidence of GC in schizophrenia patients by gender and region. The GC incidence in male schizophrenia patients (0.28%, 95%CI: 0.001-0.003; P<0.001) was higher than that in female patients (0.23%, 95%CI: 0.002-0.004). In European countries, the GC incidence in schizophrenia patients (0.98%, 95%CI: 0.005-0.008) was higher than that in Asian countries (0.13%, 95%CI: 0.000-0.002; P<0.001). Conclusion: The incidence of GC in patients with schizophrenia was 0.62%. The GC incidence was higher in male and European countries schizophrenia patients, but large cohort studies are needed to confirm further.

Published in International Journal of Gastroenterology (Volume 5, Issue 2)
DOI 10.11648/j.ijg.20210502.12
Page(s) 48-52
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Schizophrenia, Gastric Cancer, Incidence, Meta-analysis

References
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  • APA Style

    Jiacheng Gao, Yuhang Wang, Zirui Jia, Tingting Zhou, Xiangwen Zhang, et al. (2021). Incidence of Gastric Cancer in the Patients with Schizophrenia: A Meta-analysis. International Journal of Gastroenterology, 5(2), 48-52. https://doi.org/10.11648/j.ijg.20210502.12

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    ACS Style

    Jiacheng Gao; Yuhang Wang; Zirui Jia; Tingting Zhou; Xiangwen Zhang, et al. Incidence of Gastric Cancer in the Patients with Schizophrenia: A Meta-analysis. Int. J. Gastroenterol. 2021, 5(2), 48-52. doi: 10.11648/j.ijg.20210502.12

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    AMA Style

    Jiacheng Gao, Yuhang Wang, Zirui Jia, Tingting Zhou, Xiangwen Zhang, et al. Incidence of Gastric Cancer in the Patients with Schizophrenia: A Meta-analysis. Int J Gastroenterol. 2021;5(2):48-52. doi: 10.11648/j.ijg.20210502.12

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  • @article{10.11648/j.ijg.20210502.12,
      author = {Jiacheng Gao and Yuhang Wang and Zirui Jia and Tingting Zhou and Xiangwen Zhang and Guo Zu},
      title = {Incidence of Gastric Cancer in the Patients with Schizophrenia: A Meta-analysis},
      journal = {International Journal of Gastroenterology},
      volume = {5},
      number = {2},
      pages = {48-52},
      doi = {10.11648/j.ijg.20210502.12},
      url = {https://doi.org/10.11648/j.ijg.20210502.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijg.20210502.12},
      abstract = {Background: Several studies have reported the incidence of gastric cancer (GC) in the patients with schizophrenia, but the incidence of GC in schizophrenia patients remains controversy. It is necessary to perform a meta-analysis to detect the incidence of GC in schizophrenia patients. Methods: We search the relevant articles from PubMed, EMBASE, Web of Science, the Cochrane Library and Chinese electronic databases. The incidence of GC in schizophrenia patients and heterogeneity were analyzed with STATA10.0 software. Results: Our meta-analysis included total 283,422 patients with schizophrenia and 1,024 patients with GC in nine articles. The incidence of GC in schizophrenia patients was 0.62% (95%CI: 0.005-0.008; P2=98.7%). We next performed subgroup analysis to explore the incidence of GC in schizophrenia patients by gender and region. The GC incidence in male schizophrenia patients (0.28%, 95%CI: 0.001-0.003; P<0.001) was higher than that in female patients (0.23%, 95%CI: 0.002-0.004). In European countries, the GC incidence in schizophrenia patients (0.98%, 95%CI: 0.005-0.008) was higher than that in Asian countries (0.13%, 95%CI: 0.000-0.002; P<0.001). Conclusion: The incidence of GC in patients with schizophrenia was 0.62%. The GC incidence was higher in male and European countries schizophrenia patients, but large cohort studies are needed to confirm further.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Incidence of Gastric Cancer in the Patients with Schizophrenia: A Meta-analysis
    AU  - Jiacheng Gao
    AU  - Yuhang Wang
    AU  - Zirui Jia
    AU  - Tingting Zhou
    AU  - Xiangwen Zhang
    AU  - Guo Zu
    Y1  - 2021/08/02
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijg.20210502.12
    DO  - 10.11648/j.ijg.20210502.12
    T2  - International Journal of Gastroenterology
    JF  - International Journal of Gastroenterology
    JO  - International Journal of Gastroenterology
    SP  - 48
    EP  - 52
    PB  - Science Publishing Group
    SN  - 2640-169X
    UR  - https://doi.org/10.11648/j.ijg.20210502.12
    AB  - Background: Several studies have reported the incidence of gastric cancer (GC) in the patients with schizophrenia, but the incidence of GC in schizophrenia patients remains controversy. It is necessary to perform a meta-analysis to detect the incidence of GC in schizophrenia patients. Methods: We search the relevant articles from PubMed, EMBASE, Web of Science, the Cochrane Library and Chinese electronic databases. The incidence of GC in schizophrenia patients and heterogeneity were analyzed with STATA10.0 software. Results: Our meta-analysis included total 283,422 patients with schizophrenia and 1,024 patients with GC in nine articles. The incidence of GC in schizophrenia patients was 0.62% (95%CI: 0.005-0.008; P2=98.7%). We next performed subgroup analysis to explore the incidence of GC in schizophrenia patients by gender and region. The GC incidence in male schizophrenia patients (0.28%, 95%CI: 0.001-0.003; P<0.001) was higher than that in female patients (0.23%, 95%CI: 0.002-0.004). In European countries, the GC incidence in schizophrenia patients (0.98%, 95%CI: 0.005-0.008) was higher than that in Asian countries (0.13%, 95%CI: 0.000-0.002; P<0.001). Conclusion: The incidence of GC in patients with schizophrenia was 0.62%. The GC incidence was higher in male and European countries schizophrenia patients, but large cohort studies are needed to confirm further.
    VL  - 5
    IS  - 2
    ER  - 

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Author Information
  • Gastrointestinal Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China

  • Gastrointestinal Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China

  • Gastrointestinal Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China

  • Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China

  • Gastrointestinal Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China

  • Gastrointestinal Surgery, The Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China

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