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Empirical Research on the Anti-Inflammatory, Antibacterial, and Mucosal Protective Effects of Agarwood Based on the Oral and Intestinal Microenvironment

Objective: To investigate the effects of chemical substances contained in agarwood on the body's inflammatory response, oxidative stress, oral and intestinal micro-ecology, as well as their role in various mucosal diseases, such as recurrent aphthous ulcer (RAU) and inflammatory bowel disease (IBD). Materials and Methods: By reviewing and summarizing literature from the past decade on agarwood and its related chemical components composition, as well as their effects on RAU and IBD, we explore the role of agarwood in the body and its relationship with mucosal-related diseases. Results: The Specific components in agarwood, such as sesquiterpenes, flavonoids, etc., can regulate the body's inflammatory response and oxidative stress levels through various signaling pathways, thereby affecting the mucosal status of the oral and intestinal cavity, such as influencing the expression of tight junction proteins between epithelial cells to restore mucosal barrier permeability. Conclusion: Agarwood can down-regulate the inflammatory response by inhibiting various signaling pathways, mainly NF-κB, reduce oxidative stress by decreasing ROS expression, improve the mucosal barrier in the oral and intestinal cavity, and simultaneously impact the improvement of oral and intestinal micro-ecology. It plays a certain controlling role in mucosal-damaged diseases such as IBD and RAU, laying the foundation for the transformation, development, and upgrading of the agarwood industry.

Agarwood, Anti-Inflammatory, Flavonoids

APA Style

Yi-Nan Zhang, Zi-Lin Wang, Xiang Guo, Xue-Jing Lin, Hao-Yi Duan, et al. (2023). Empirical Research on the Anti-Inflammatory, Antibacterial, and Mucosal Protective Effects of Agarwood Based on the Oral and Intestinal Microenvironment. International Journal of Gastroenterology, 7(2), 49-53.

ACS Style

Yi-Nan Zhang; Zi-Lin Wang; Xiang Guo; Xue-Jing Lin; Hao-Yi Duan, et al. Empirical Research on the Anti-Inflammatory, Antibacterial, and Mucosal Protective Effects of Agarwood Based on the Oral and Intestinal Microenvironment. Int. J. Gastroenterol. 2023, 7(2), 49-53. doi: 10.11648/j.ijg.20230702.12

AMA Style

Yi-Nan Zhang, Zi-Lin Wang, Xiang Guo, Xue-Jing Lin, Hao-Yi Duan, et al. Empirical Research on the Anti-Inflammatory, Antibacterial, and Mucosal Protective Effects of Agarwood Based on the Oral and Intestinal Microenvironment. Int J Gastroenterol. 2023;7(2):49-53. doi: 10.11648/j.ijg.20230702.12

Copyright © 2023 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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